Good Trouble follows the lives of two sisters, Callie and Mariana, as they navigate their early twenties in Los Angeles. After moving into a communal living apartment building called The Coterie, they must balance love, sex, and complicated relationships while pursuing their careers. Callie works as a law clerk for a conservative judge while Mariana starts her career as a software engineer. Together, they face the challenges of adulthood and independence in a new city.

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Some TV shows that have similar genres and were produced around the same time as Good Trouble include A Man in Full, Lessons in Chemistry, The Newsroom, Normal People, The Good Wife, Chernobyl.