In a post-apocalyptic world, teenager Rex has a unique gift: the ability to turn his body into powerful machines. Recruited by a secret organization, Rex uses his powers to battle against dangerous monsters and save humanity from extinction. But as he fights to protect the world, Rex must also confront his own demons and uncover the truth about his mysterious past. With the fate of humanity in his hands, Rex must choose between his loyalty to Providence and his own desire for freedom.

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Some TV shows that have similar genres and were produced around the same time as Generator Rex include Dora the Explorer, The Adventures of the Young Marco Polo, Pokémon Master Journeys, Spirit Riding Free: Riding Academy, Pokémon: The Arceus Chronicles, Pokémon Concierge.