In a harsh world, a young woman and a middle-aged man find solace in each other's company. They form an unlikely bond, sheltering each other from the weight of their own struggles. As they navigate their difficult lives, they discover comfort, warmth, and perhaps even a chance at healing. But can their fragile connection survive the challenges that threaten to tear them apart?

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Some TV shows that have similar genres and were produced around the same time as My Mister include Lessons in Chemistry, Chernobyl, Mad Men, Shardlake, Normal People, Nashville.