In a low-income neighborhood, three friends navigate their way through life's challenges with a healthy dose of humor and hope. Despite their dysfunctional families and questionable romantic relationships, they support each other and find ways to make the best of their situation. Together, they prove that laughter and friendship can help overcome even the toughest obstacles.

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Some TV shows that have similar genres and were produced around the same time as Can You Hear Me? include Dead Boy Detectives, The Big Door Prize, Bad Sisters, One Day, The Bear, This Is Us.