In this animated comedy series, two high school girls, Haruka and Yuu, who have been inseparable since middle school, try to make their relationship special by kissing each other in secret. However, their friendship is put to the test when they are seated on opposite sides of the classroom and start to attract attention from their classmates. As they navigate their new high school life, they must confront their feelings for each other and decide what their relationship means to them. With a unique blend of humor, romance, and drama, this show explores the ups and downs of teenage friendships and relationships.

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Some TV shows that have similar genres and were produced around the same time as Sakura Trick include Hazbin Hotel, Family Guy, Bob's Burgers, Stroker and Hoop, Migi&Dali, Stripperella.