After years away from the CIA, Elizabeth McCord is pulled back into the political arena as the newly appointed Secretary of State. A college professor turned government official, she must navigate international crises, office politics, and her family life while driving diplomacy and negotiations. As she battles to make a difference in a male-dominated world, Elizabeth's upfront and unconventional approach sparks both admiration and resistance. From the White House to foreign capitals, this powerful drama follows a woman's journey to make a mark on history while keeping her family intact.

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Some TV shows that have similar genres and were produced around the same time as Madam Secretary include Shōgun, Fallout, The Looming Tower, Masters of the Air, Band of Brothers, All the Light We Cannot See.