In the small town of Parkersburg, West Virginia, a group of citizens uncovers a shocking truth about the local DuPont chemical plant.s dumping of toxic chemicals into the drinking water supply. A group of citizens, including a farmer whose cattle are dying mysteriously and a woman whose children are born with facial deformities, band together to take on the powerful corporation. As they delve deeper into the truth, they discover that DuPont has knowingly been polluting the water for decades, With the chemical C8, used to produce Teflon, linked to a multitude of cancers and birth defects. The film-makers expose the devastating consequences of corporate greed and lack of accountability, raising questions about the safety of our food, water, and environment.

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Some movies that have similar genres and were produced around the same time as The Devil We Know include On Putin's Blacklist, Homme Less, Night of the Fight: Hatton's Last Stand, Women Behind Bars with Trevor McDonald, Iris, Salam Neighbor.