In this psychological horror film, a young and deeply religious nurse named Maud is assigned to care for a terminally ill patient named Amanda, who is confined to her grand home. As Maud becomes increasingly obsessed with saving Amanda's soul, she begins to unravel mentally and physically. The lines between reality and delusion blur as Maud becomes convinced that she has received divine messages tasking her with the mission of saving Amanda from eternal damnation. The tension between Maud's faith and Amanda's hedonistic lifestyle creates an atmosphere of suspense and unease as the audience waits to see if Maud will succeed in her mission or succumb to her own darkness.

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Some movies that have similar genres and were produced around the same time as Saint Maud include Last Night in Soho, Suspiria, The Invisible Man, The Witch, A Haunting in Venice, Midsommar.