Ray Breslin, a security expert who specializes in rescuing people from the world's most secure prisons, must return to the secret prison he once escaped from to save his friend Shu Ren, who has been kidnapped and forced to fight for survival in a high-tech arena known as Hades. With the help of his team, including Trent DeRosa and surveillance expert Hush, Breslin must navigate the prison's ever-changing layout and face off against the ruthless warden, Gregor Faust, and his former colleague, Jasper Kimbral, who has taken over the prison and is using it to extract valuable information from its inmates. As Breslin and his team race against time to rescue Shu and escape the prison, they uncover a sinister plot to use the prison's technology for nefarious purposes, and must fight to survive and bring the truth to light.

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Some movies that have similar genres and were produced around the same time as Escape Plan 2: Hades include The Price We Pay, Ghost in the Shell, Killers Anonymous, Glamour, Red Stone, Last Three Days.