Trapped in a high-tech office building, a slacker named Desmond and his coworkers must fight for their lives against a horde of zombie-like colleagues who have been transformed by a military-issued energy drink. With the help of his crush Samantha and friend Mourad, Desmond must navigate the building's deadly obstacles, rescue their boss Franklin, and find an antidote to cure Samantha before it's too late. As they fight their way through the hordes of violent psychopaths, they uncover the dark truth behind the Zolt energy drink and the sinister motives of their CEO. Will they be able to escape the Office Uprising alive, or will they become the next victims of this deadly corporate conspiracy?

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Några filmer som har liknande genrer och producerades ungefär samtidigt som Office Uprising inkluderar Day Shift, Chinese Speaking Vampires, The VelociPastor, Tremors 5: Bloodlines, Daphne & Velma, Slaughterhouse Rulez.