"A woman struggling with alcoholism and unemployment finds herself connected to a mysterious, destructive creature that's terrorizing a city on the other side of the world. As she tries to understand and control her connection to the monster, she discovers a dark secret from her childhood that may hold the key to stopping the creature's rampage." This description sets up the central conflict of the movie without giving away any spoilers, while also highlighting themes of personal struggle and redemption. It also creates a sense of intrigue by mentioning the mysterious connection between the protagonist and the monster, which will pique viewers' interest and encourage them to watch.

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Noen filmer med lignende sjangre og produsert rundt samme tid som Colossal inkluderer Dune: Part One, The Midnight Sky, The Zero Theorem, Archive, Undergods, Black Mirror: Bandersnatch.