Cocaine Cowboys II: Hustlin' with the Godmother tells the story of Charles Cosby, a small-time cocaine dealer who becomes embroiled in a dangerous game of power and greed when he writes a fan letter to the "Cocaine Godmother," Griselda Blanco, who is serving time in federal prison. Cosby's life is forever changed as he becomes Blanco's lover and the head of her $40 million a year cocaine business. But as he delves deeper into the criminal underworld, Cosby soon learns that he's in way over his head and must navigate a treacherous web of drugs, violence, and betrayal to survive.

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Some movies that have similar genres and were produced around the same time as Cocaine Cowboys II: Hustlin' with the Godmother include Jeremy Jones' Deeper, Minds in the Water, Top Gear: At the Movies, Nitro Circus: The Movie, American Federale, David Knight - Iron Man of Enduro.

Cocaine Cowboys II: Hustlin' with the Godmother was released in theaters on July 29, 2008.