Wild at Heart follows the adventures of a British veterinarian and his family as they leave their mundane life behind and embark on a new journey in the African savannah. Danny Trevanion, played by Stephen Tompkinson, is a skilled vet who has lost his passion for his work. When the opportunity to run a wild game reserve in South Africa presents itself, Danny jumps at the chance, bringing his wife Sarah, played by Amanda Holden, and their three children along for the ride. As they settle into their new home, they face challenges from both the wild animals they're tasked with protecting and the harsh environment that surrounds them. With the help of their new friends and colleagues, the Trevanions learn to work together and find purpose in their lives, all while navigating the unpredictable landscape of Africa.

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Some TV shows that have similar genres and were produced around the same time as Wild at Heart include Hell House, Obsession: Dark Desires, Home Alone, Testament: The Story of Moses, Jaguar, Disappeared.