In the gritty streets of South Philadelphia, a group of depraved and disillusioned friends run a dingy Irish bar called Paddy's Pub. Their lives are filled with scheming, booze, and reckless behavior, as they constantly try to outsmart each other and the world around them. But their selfish antics often backfire, leading to chaos, destruction, and hilarious comeuppances. With no shortage of dark humor and satire, this show delves into the depths of human depravity and codependency.

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Some TV shows that have similar genres and were produced around the same time as It's Always Sunny in Philadelphia include Modern Family, Parks and Recreation, Schitt's Creek, Kim's Convenience, Friends, The Office.