In rural New England, a young couple's car breaks down during an investigation of a local fungus outbreak. Seeking shelter, they encounter an eccentric old woman and her mute son, who offer them food and shelter. But as they soon discover, the family's strange behavior hides a dark and sinister secret, one that could cost the couple their lives. As they become trapped in the farmhouse, hallucinations, and cravings take hold, and the line between reality and nightmare blurs. Will they survive the horrors of Honeydew?

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Some movies that have similar genres and were produced around the same time as Honeydew include Late Night With the Devil, Immaculate, Terrified, Infested, The Exorcist: Believer, Lovely, Dark, and Deep.