Swamp Thing follows CDC researcher Abby Arcane as she investigates a deadly virus that appears to originate from a Louisiana swamp. She develops a bond with scientist Alec Holland, but he is tragically killed. Abby discovers that the swamp holds mystical and terrifying secrets and that Alec may not be dead after all. As powerful forces descend upon the town, intent on exploiting the swamp's mysterious properties, Abby must confront the horrors that lurk within and uncover the truth about Alec's fate.

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Some TV shows that have similar genres and were produced around the same time as Swamp Thing include 3 Body Problem, Dark, Severance, Supernatural, Under the Dome, Charmed.