Deep in the heart of Florida's swamplands,, two brothers are on a mission to protect the state's most dangerous and exotic reptiles. Meet Robbie Keszey, an expert in exotic animals, and his brother Stephen, a city boy turned swamp dweller. Together, they run Glades Herp Farms - the largest reptile sanctuary and exotic reptile dealership in Florida. Watch as they track down alligators lurking in backyards, wrangle venomous snakes in the Everglades, and wrangle dangerous predators that threaten their sanctuary. The Swamp Brothers are fighting to protect both the people and the wildlife of Florida, one creature at a time.

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Some TV shows that have similar genres and were produced around the same time as Swamp Brothers include Expedition X, Roots Less Traveled, Extraordinary Acts of Courage, Quest For The Bay, Dark Days in Monkey City, When Vacations Attack!.