In this romantic comedy-mystery series set in the Joseon era, a cold and unlikable Crown Prince named Lee Yool (D.O.) loses his memory after being attacked by assassins arranged by his ambitious uncle, Kim Cha-eon. He wanders the countryside as a commoner and meets Hong Sim (Nam Ji Hyun), a smart and compassionate woman who runs a detective agency. Despite their different backgrounds and personalities, they begin to fall in love as they work together to solve a mystery, while Hong Sim also helps Lee Yool to regain his memories. As they navigate their complicated relationship and uncover the truth about each other's past, they must confront the power struggles within the royal palace that threaten to tear them apart. With a unique blend of humor, romance, and mystery, "100 Days My Prince" offers a refreshing take on traditional royal dramas while exploring themes of identity, family, and love.

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Some TV shows that have similar genres and were produced around the same time as 100 Days My Prince include Dead Boy Detectives, Avatar: The Last Airbender, Charmed, Imposters, Monk, Psych.