In a future where convicts can volunteer for medical experiments to shorten their sentences, a young inmate named Jeff (Miles Teller) begins to question the true purpose of the research at the state-of-the-art Spiderhead Penitentiary. As he becomes embroiled in a dangerous game of cat and mouse with the facility's enigmatic leader, Steve Abnesti (Chris Hemsworth), Jeff must confront his own dark past and the blurred lines between reality and manipulation. With the help of his fellow inmate and love interest Lizzy (Jurnee Smollett), Jeff must fight for survival and uncover the sinister truth behind the facility's ultramodern facade. This description captures the essence of the movie's themes, plot, and characters without revealing any spoilers or references to the cast and crew. It highlights the unique concept of using prisoners as medical test subjects and the main character's journey of self-discovery and survival within the sinister environment of Spiderhead Penitentiary.

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Some movies that have similar genres and were produced around the same time as Spiderhead include Code 8 Part II, Mondocane, The Batman, 21 Bridges, The Killer, To Catch a Killer.