In this campy, sci-fi comedy, a Japanese scientist accidentally unleashes a giant monster that feeds on beer, causing chaos in Cincinnati. The race is on to save the city as the monster grows taller than a skyscraper, while a crazed nuclear physicist plots to destroy both the monster and the city. With the help of a local brewmeister, the scientists must use an "anti-beer" formula to return the monster to its normal size and prevent further destruction. But as the monster wreaks havoc, the scientists discover a secret weapon that could irradiate the city for 50 years. Will they be able to save Cincinnati and the world from this beer-guzzling menace?

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Some movies that have similar genres and were produced around the same time as Notzilla include Everything Everywhere All at Once, Absolutely Anything, Elemental, Spider-Man: Across the Spider-Verse, Ghostbusters: Afterlife, The Super Mario Bros. Movie.