In a future world where Mars is partially terraformed, two young women from different walks of life come together to chase their dreams of making it big in the music industry. Carole Stanley, an orphaned refugee from Earth, and Tuesday Simmons, a wealthy politician's daughter, form an unlikely duo, using their unique musical talents to create something truly special. With Carole's powerful voice and Tuesday's skill on the guitar, they take the stage as Carole & Tuesday, determined to make a name for themselves in the bustling city of Alba. Will their partnership be strong enough to overcome their differences and achieve success, or will their contrasting backgrounds tear them apart?

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Algumas séries de TV de gêneros semelhantes e que foram produzidas na mesma época que Carole & Tuesday incluem Iwájú, The Legend of Korra, Made In Abyss, The Founder of Diabolism, My Happy Marriage, Pluto.