Murder Mystery follows Nick and Audrey Spitz, a New York City cop and his hairdresser wife, as they embark on a long-awaited trip to Europe. After they meet billionaire Charles Cavendish on the plane, he invites them to join him on his family yacht for a party. When Cavendish's uncle Malcolm Quince is found stabbed to death, Nick and Audrey team up with Inspector Delacroix to solve the murder. As they investigate, they uncover secrets and motives that lead them from Monte Carlo to Lake Como, all while trying to strengthen their own marriage. With plenty of twists and turns along the way, Murder Mystery is an action-packed comedic whodunit that will keep you guessing until the very end.

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Some movies that have similar genres and were produced around the same time as Murder Mystery include Pokémon Detective Pikachu, Detective Chinatown, War on Everyone, Now You See Me 2, Detective Chinatown 3, Skiptrace.