When a private nurse and her two children move into a secluded mansion to care for an elderly man, they unleash a terrifying entity that takes the form of a giant spider. As the spider wreaks havoc on their lives, the family must confront their darkest fears and secrets to survive. But as they fight for their lives, they realize that the spider may not be the only danger lurking in the shadows. Will they be able to escape the deadly web of Itsy Bitsy, or will they become its next victims?

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Some movies that have similar genres and were produced around the same time as Itsy Bitsy include Speak No Evil, Talk to Me, Split, Nope, Gerald's Game, Pearl.