In 19th century Edinburgh, two struggling Irish immigrants, William Burke and William Hare, stumble upon a lucrative business idea - providing fresh cadavers for the city's prestigious medical school. As demand for corpses skyrockets, Burke and Hare resort to murder to keep up with orders, but their partnership with a local anatomist, Dr. Knox, eventually leads to their downfall. A dark comedy based on true events, Burke & Hare delves into themes of greed, love, and the ethics of scientific progress, set against the backdrop of a bustling Scottish city.

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Some movies that have similar genres and were produced around the same time as Burke & Hare include The Servant, The Battle of Pussy Willow Creek, Not the Messiah (He's a Very Naughty Boy), Charlie Wilson's War, Made in Dagenham, Heneral Luna.